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The Truth About Sativex
13 Jan 2012
Originally published 19th October 2010
Sativex is super strong, concentrated cannabis. Nothing more, nothing less.
GW Pharmaceuticals would have you believe that it's a "pharmaceutical" product because according to its research that's what patients prefer. As the GW spokesman puts it, "It's a pharmaceutical solution, formulated with the ability to deliver a precise dose and with stringent standards of quality, safety and efficacy".
In fact, what GW does is grow high quality cannabis under pretty much the same conditions as most illegal growers. It uses clonal propagation to ensure consistent levels of cannabinoids. Lighting and hydroponic nutrition is computer controlled with automatic ventilation. It really is no different from the most sophisticated and efficient illegal cannabis farms. It's a recognised and proven technology now also used by Bedrocan in Holland, the Dutch government's exclusive medicinal cannabis grower and Gropech in California which is building a new 60,000 sq ft facility in Oakland for an annual harvest worth $50 million.
The difference between these crops from legal and illegal growers is insignificant. It's similar to buying your tomatoes from the supermarket or the farm shop.
GW takes its high quality cannabis, chops it up and makes a tincture by heating it under pressure with CO2 and then adding ethanol to precipitate an oil. Then, with the addition of a little peppermint oil to mask the taste and some preservative, the filtered liquid is packaged into tiny little aerosol bottles. Each spray delivers 2.7mg of THC and 2.5mg of CBD. What GW doesn't tell you that it also contains all the other 100+ cannabinoids found in the plant, each of which has its own mechanism of action and effect. It also contains flavonoids, terpines and other compounds. Everything that is found in the plant.
I applaud GW Pharmaceuticals for bringing the enormous benefits of cannabinoid therapy into the 21st century. It's nothing new though. The medicinal value of the plant has been known and widely used for thousands of years. Only in the last century has it been demonised by lies and propaganda. It would be a mistake though to think that Sativex is anything different from the plant itself. It's just been wrapped up in a marketing and physical package which has enabled stupid and cowardly politicians to accept it.
In fact, Sativex remains just as illegal in Britain as herbal cannabis. Even though it has received MHRA approval for use in the treatment of MS spasticity and may be prescribed by a doctor, it remains a schedule 1 drug under the Misuse Of Drugs Act 1971. The Home Office has indicated that it intends to amend the law but has not yet done so. This means that any pharmacist who dispenses Sativex at present would be guilty of exactly the same criminal offence as any street dealer in weed or hash.
The Home Office will, of course, turn a blind eye to this but not to medicinal herbal cannabis even though, in every sense, it is identical to Sativex (except that Sativex also contains alcohol and peppermint oil). The stark idiocy of British law is revealed.
Never before has there been a better example of the how the law is an ass and so are the spineless politicians who support it.
In 2011 the Home Office issued what it calls an "Open General Licence" for Sativex allowing it to be prescribed and dispensed. A doctor may prescribe Sativex for its approved purposed "spasticity in MS" or, "off label", for any condition he or she believes it to be beneficial for. However, "off label" prescriptions are the doctor's personal responsibility so it is easy to understand why doctors may be hesitant to do so.
Most PCTs and health authorities are refusing to fund Sativex because of the extraordinarily high price that GW and its UK distributors Bayer want to charge the NHS. At about £175 per bottle, Sativex costs around 10 times what organised crime sells cannabis for on the streets. Products that are pharmacologically identical to Sativex are available from medical marijuana dispensaries in the US for around $20 per bottle (usually containing much more than the GW product). Alta California offers three varieties of a Sativex-type tincture with different cannabinoid ratios for different purposes.
In June 2011, CLEAR and Action4MS announced a joint venture Access Sativex which will seek to organise and help people apply for Sativex.
The Advisory Council on the Misuse of Drugs (ACMD) has recommended that Sativex be placed in schedule four of the Misuse of Drugs Act 1971 (MoDA). The chair, Professor Les Iversen, wrote to the Home Office on 14th January 2011 with this advice but nothing has been done. It is easy to understand why. As Professor Iversen wrote: "The ACMD is also aware that it will not be appropriate to refer to "Sativex", which is a proprietary name, in any amendment to the misuse of drugs regulations, and that a suitable description of the relevant component(s) of "Sativex" will have to be scheduled".
There is no honest or accurate way to describe Sativex except to say that it is cannabis. The Home Office is on the record as saying that "the future scheduling of this medicinal product will not affect the classification of cannabis" which is unambiguous evidence of an intention to deceive.
Perhaps the most important truth to emerge from this story of deceit and disinformation is the statement made by Professor H.P. Hartung, Chair of Neurology at Heinrich-Heine University, Dusseldorf, Germany on 24th October 2011. He was commenting on data from three Phase III trials involving over 1,500 MS patients as well as first everyday clinical practice data were presented by a panel of international experts at the European Congress of Multiple Sclerosis (ECTRIMS) in Amsterdam.
"Sativex® has proven to reduce the severity of symptoms and improve patients' quality of life and functional status, in patients with spasticity in multiple sclerosis, meaning that they can undertake everyday tasks more easily. Also, importantly, clinical experience to date has demonstrated that the tolerability profile of this medicine is favourable, with limited relevant adverse effects and - particularly reassuring - the drug does not appear to lead to withdrawal effects if patients suddenly stop using it."